Obesity and Metabolic Research at UAMS

Obese people are more likely to develop diabetes. Prior to the development of diabetes, many people have "Impaired Glucose Tolerance". Impaired glucose tolerance is a condition where your blood sugar is normal when fasting (before you eat), but is too high after drinking a sugary drink. Impaired glucose tolerance often leads to diabetes.

You are invited to participate in a research study on this pre diabetic condition. You will qualify for this study if you are

• Above ideal body weight (BMI between 28-38)
• Between 35 –65 year old
• Impaired glucose tolerant (IGT)

This study is designed to test the effects of two different drugs (pioglitazone and metformin) on numerous features of this condition including insulin secretion and metabolism, fat metabolism and fat accumulation in the body (including muscle). These drugs, pioglitazone and metformin, are commonly used to treat diabetes.

If you qualify and choose to participate, studies involving blood sampling, fat and muscle biopsies will be performed before and after 10 weeks of taking one of the above medications.

The compensation will be $625 for the completion of the study.

For more information please call Leslie Miles @ 501-257-5893