Obesity and Metabolic Research at UAMS

Recent Publications

1. Ong JM, Kern PA. 1989. The effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue. J. Clin. Invest. 84:305-311.
   
   
2. Kern PA, Ong JM, Saffari B, Carty J. 1990. The effects of weight loss on the expression of adipose tissue lipoprotein lipase in very obese humans. N. Engl. J. Med. 322:1053-1059.
   
   
3. Wallace DJ, Metzger AL, Stecher VJ, Turnbull BA, Kern PA. 1990. Cholesterol-lowering effect of hydroxychloroquine (Plaquenil) in rheumatic disease patients. Reversal of deleterious effects of steroids on lipids. Am. J. Med. 89:322-326.
   
   
4. Ong JM, Saffari B, Simsolo RS, Kern PA. 1992. Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in post-transcriptional processing. Mol. Endocrinol. 6:61-69.
   
   
5. Simsolo RB, Ong JM, Saffari B, Kern PA. 1992. The effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue. J. Lipid Res. 33:89-95.
   
   
6. Wolfe GR, Trozzolino LA, Kern PA . 1993. Exogenous obesity: what actually works. Hospital Medicine 29:112-119.
   
   
7. Simsolo RB, Ong JM, Kern PA. 1993. Effect of gemfibrozil on adipose tissue and muscle lipoprotein lipase. Metabolism 42:1486-1491.
   
   
8. Simsolo RB, Ong JM, Kern PA. 1993. The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining. J. Clin. Invest. 92:2124-2130.
   
   
9. Kern PA, Trozzolino L, Wolfe G, Purdy L. 1994. Combined use of behavior modification and very-low calorie diet in weight loss and weight maintenance. Am. J. Med. Sci. 307:325-328.
   
   
10. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. 1995. The expression of tumor necrosis factor in human adipose tissue: regulation by weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95:2111-2119.
    
    
11. Simsolo RB, Ezzat S, Ong JM, Saghizadeh M, Kern PA. 1995. Effects of growth hormone and acromegaly on adipose tissue lipoprotein lipase. J. Clin. Endocrinol. Metab. 80:3233-3238.
    
    
12. Maffei M, Halaas J, Ravussin E, Pratley RE, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. 1995. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nature Medicine 1:1155-1161.
    
    
13. Kern PA. 1995. High adipose tissue lipoprotein lipase activity plays a causal role in the aetiology of obesity. Progress in Obesity Research 94, Angel, A. et al, eds. John Libbey & Co, Ltd., London.
    
    
14. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. 1996. The expression of TNFa by human muscle: relationship to insulin resistance. J. Clin. Invest. (Rapid Publication) 97:1111-1116.
    
    
15. Maheux P, Azhar S, Kern PA, Chen Y-DI, Reaven GM. 1997. Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia. 40:850-858.
    
    
16. Kern PA. 1997. Potential role of TNFa and lipoprotein lipase as candidate genes for obesity. J. Nutrition 127:1917S-1922S.
    
    
17. Kern PA. 1997. A prudent and practical approach to the treatment of obesity. J. Arkansas Med. Soc. 94:191-197.
    
    
18. Ranganathan S, Maffei M, Kern PA. 1998. Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relation with adipose TNFa expression. J. Lipid Res. 39:724-730.
    
    
19. Ranganathan S, Ciaraldi TP, Henry RR, Mudaliar S, Kern PA. 1998. Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells. Endocrinology. 139:2509-2513.
    
    
20. Ranganathan S, Kern PA. 1998. Thiazolidinediones inhibit lipoprotein lipase activity in adipocytes. J. Biol. Chem. 273:26117-26112.
    
    
21. Ciaraldi TP, Abrams-Carter L, Mudaliar S, Kern PA, Henry RR. 1998. Effects of TNFa on glucose metabolism in cultured human muscle cells from non-diabetic and type 2 diabetic subjects. Endocrinology. 139:4793-4800.
    
    
22. Barnard RJ, Berger JJ, Ong JM, Kern PA. 1998. Adipocyte and muscle changes in response to diet leading to obesity. Diabetes Research 33:213-228.
    
    
23. Kern PA, Simsolo RB, Fournier M. 1999. Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans. J. Clin. Endocrinol. Metab type, fiber size, capillarity, and succinate dehydrogenase activity in humans. J. Clin. Endocrinol. Metab. 84:4185-4190.
    
    
24. Ranganathan G, Kaakaji R, Kern PA. 1999. Role of protein kinase C in the translational regulation of lipoprotein lipase in adipocytes. J. Biol. Chem 274:9122-9127..
    
    
25. Fonseca V, Dicker-Brown A, Ranganathan S, Barnard RJ, Fink L, Kern PA. 2000. Effects of insulin resistance on enzymes of homocysteine metabolism in the rat. Metabolism. 49:736-741.
    
    
26. Cranmer M, Louie S, Kennedy RH, Kern PA, Fonseca VA. 2000. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. Tox. Sci. 56:431-436.
    
    
27. Ranganathan G, Li C, Kern PA. 2000.Translational regulation of lipoprotein lipase in diabetic rats involves the 3’ untranslated region of the LPL mRNA. J. Biol. Chem. 275:40986-40991.
    
    
28. Dicker-Brown A, Fonseca VA, Fink LM, Kern PA. 2001. The effect of glucose, insulin and insulin resistance on the activity of methylene tetrahydrofolate reductase and cystathionine-b-synthase: studies in Hep G2 cells and the ob/ob mouse. Atherosclerosis. 158:297-301.
    
    
29. Kern PA, Ranganathan S, Li C, Wood L, and Ranganathan G. 2001. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity–associated insulin resistance. Am. J. Physiol. Endocrinol Metab. 280:E745-E751.
    
    
30. Ranganathan S, Kern PA. 2002. The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes. J. Endocrinology 172:155-162.
    
    
31. Ranganathan G, Song W, Dean N, Barger SW, Kern PA. 2002. Regulation of lipoprotein lipase by protein kinase Ca in 3T3-F442A adipocytes. J. Biol. Chem. 277:38669-38675.
    
    
32. Ranganathan G, Phan D, Pokrovskaya ID, McEwen JE, Li C, Kern PA. 2002. The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A. J. Biol. Chem. 277: 43281-43287.
    
    
33. Fonseca VA, Fink LM, Kern PA. 2003. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis. 167:105-109.
    
    
34. Kern PA, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. Adiponectin expression from human adipose tissue: relationship to obesity, insulin resistance and TNFa expression. Diabetes. In press.